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Internal Medicine News - Digoxin poses risk in women

admin — Mon, 05 Jan 2009 19:17:24 +0000

Digoxin appears to raise the risk of death in stable heart failure, but only in women, according a post hoc analysis of data from a clinical trial.
This finding is based on “robust evidence” and “provides sufficient grounds for a reexamination of the use of digoxin therapy for women with heart failure,” said Saif S. Rathore, a public health specialist at Yale University, New Haven, and associates.
In 1997 the Digitalis Investigation Group reported that digoxin decreased the rate of hospitalization for worsening heart failure, based on a clinical trial involving nearly 8,000 patients at 302 clinical centers. The American College of Cardiology the American Heart Association, and the Heart Failure Society of America then issued guidelines strongly endorsing the use of digoxin in patients with heart failure.

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The Yale researchers decided to reassess the data because the study had enrolled four men for every woman. The post hoc analysis showed a 5.8% absolute difference between men and women in the drug’s effect on mortality. Digoxin raised the rate of death from any cause, death from cardiovascular causes, and death from worsening heart failure only in women (N. Engl. J. Med. 347[18]:1403-11, 2002).
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Southern Medical Journal - Early detection of digitalis-induced nonocclusive mesenteric ischemia using Doppler ultrasonography.(Letter to the editor)

admin — Sun, 04 Jan 2009 13:52:47 +0000

To the Editor: Acute mesenteric ischemia occurs in 1 of 1000 hospital admissions, and a nonocclusive mechanism makes up about 20% of these cases. (1) Nonocclusive mesenteric ischemia (NOMI) is a condition where the macrovasculature is patent, but the microvascular blood flow is inadequate to meet intestinal tissue demands leading to gangrene and disastrous consequences.

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The pathophysiology of NOMI involves low blood flow states such as shock, heart failure, hemodialysis and direct splanchnic arteriolar vasoconstriction by drugs, eg, digoxin. (2,3) Angiography is the gold standard …

Read the rest of this article with a Free Trial at HighBeam Research.

Journal of Family Practice - Optimal digoxin range for men is 0.5 to 0.8 ng/mL

admin — Wed, 31 Dec 2008 10:49:08 +0000

Rathore SS, Curtis JP, Wang Y, Bristow MR, Krumholz, HM. Association of serum digoxin concentration and outcomes in patients with heart failure. JAMA 2003; 289:871-878.
* PRACTICE RECOMMENDATIONS
The optimal serum drug concentration for digoxin among men in sinus rhythm with stable heart failure is 0.5 to 0.8 ng/mL. This range is associated with decreased risk of hospitalization and mortality compared with placebo. Higher levels are associated with either no reduction, or an increased risk of hospitalization and mortality compared with placebo.
* BACKGROUND

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The Digitalis Investigation Group (DIG) trial of patients with heart failure found no effect on mortality from digoxin therapy at serum concentrations of 0.5 to 2.0 ng/mL, but did find that hospitalization due to worsening heart failure was modestly reduced. The original investigators did not evaluate the relative efficacy of different concentrations.
Other studies have demonstrated an association between serum drug concentrations 4 signs or symptoms of heart failure. Other medications known to benefit heart failure, such as angiotensin-converting enzyme inhibitors and diuretics, were continued. Patients using digoxin at the time of enrollment could be allocated to drug or placebo.
* STUDY DESIGN AND VALIDITY
This study is a post-analysis of data collected from the DIG study. The DIG study was a double-blind, placebo-controlled study of digoxin in the treatment of heart failure. Digoxin dosing was based on a published algorithm; serum digoxin levels were drawn 1 month after randomization. The present study is a subgroup analysis of men based on serum drug concentrations at 1 month of 0.5-0.8 ng/mL, 0.9-1.1 ng/mL, or [greater than or equal to] 1.2 ng/mL. These ranges have been used in previous studies of digoxin in the treatment of heart failure.
The study was sufficiently well done to draw conclusions about use of digoxin in treatment of heart failure. Patients and data investigators were blinded with respect to treatment, and cause of death was determined without knowledge of assigned treatment group. Digoxin levels were reported from the 1 month visit only. No subsequent levels were documented.
Generalizability to the general population is limited, as only men with heart failure in sinus rhythm and a left ventricular ejection fraction

HealthDay - 3 Common Drugs Trigger Most ER Visits by Seniors

admin — Mon, 29 Dec 2008 15:09:44 +0000

Side effects from just three drugs are responsible for a full third of all U.S. emergency room visits by senior citizens who had adverse reactions to medications, a new study found.
In 2004 and 2005, the blood thinner warfarin, the diabetes drug insulin and the heart drug digoxin caused about 58,000 emergency room visits a year in those 65 and older, the researchers found.
The major problem is that it’s hard to determine the correct dose for each drug, said study lead author Dr. Daniel Budnitz, a medical officer with the U.S. Centers for Disease Control and Prevention (CDC).
“It’s challenging,” he said, “and it takes work between the patient and physician to get the dose just right.”

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Budnitz and his colleagues undertook the study to determine the danger posed to senor citizens by a long list of drugs that have been deemed “potentially inappropriate” …

Read the full article with a Free Trial at MyWire.

Chain Drug Review - Lannett fills gap

admin — Sun, 28 Dec 2008 14:30:04 +0000

PHILADELPHIA — Lannett Co. is working to ensure a supply of the heart failure drug digoxin following a recall of another version of the drug. The FDA said that Digitek tablets may contain twice the amount of the active ingredient, which could put patients at risk, including the possibility of death.

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Independent on Sunday, The - NUMBERS

admin — Tue, 23 Dec 2008 22:41:38 +0000

$1 trillion
The interest America will have paid by 2017 on the money borrowed to finance the war in Iraq
13 billion
The number of plastic bags issued to shoppers every year in the UK
3
Number of drugs (warfarin, insulin and digoxin) that are responsible for a third of all serious adverse drug reactions among over-65s, according to a survey in the ‘Annals of Internal Medicine’
72%
Rise in the number of deaths linked to Clostridium difficile in the past year
5,000,000,000

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Cumulative hours waited for web pages to download this year
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LegalView Reports of Woman Allegedly Fired For Expressing Concerns with Asbestos-Tainted Flooring At Her Workplace

admin — Sun, 21 Dec 2008 02:02:33 +0000

LegalView updated its mesothelioma blog with information of a woman who was allegedly fired for openly discussing her concerns with asbestos-tainted flooring. The woman, who works at a nursing home beauty salon, claims she was fired after she expressed anxiety with over her health because of potential asbestos exposure.

Denver, CO (PRWEB) May 23, 2008 — LegalView, the most comprehensive resource for everything legal on the Web, recently offered readers updated mesothelioma information through its mesothelioma blog. The story concerns a woman who was allegedly fired for expressing her concerns with asbestos-tainted flooring in her workplace. The woman, Mary Ann Gruzs, worked as a beautician in a York County, Penn., nursing home and claims she was fired in 2006 from her job after pointing out concerns with potential asbestos in the flooring, which may have put her health at risk as well as increase her chances of developing mesothelioma. Individuals who feel they too have been placed at risk with asbestos-tainted workplace environments should contact an experienced mesothelioma law firm to learn more about how to protect their health.

Mesothelioma is a deadly form of cancer that can remain dormant in the body for years, and, in most instances decades. It is caused when an individual has been exposed to asbestos fibers and asbestos dust. Those who believe they may have been previously exposed to asbestos should consult a medical professional immediately, as mesothelioma is often misdiagnosed and only through early treatment do individuals have a better chance of fighting the illness. Additionally, locating a mesothelioma lawyer may be advisable as well.

Asbestos, derived from the mineral vermiculite, was widely mined and used as insulation in buildings, ships and homes/apartments across the United States. It was considered an ideal insulator for its cheap production costs as well as its resistance to catching fire. However, after years of production and implementation across the country, the symptoms associated with mesothelioma and asbestos began to become apparent. Although its use was banned in the United States, it was not before thousands may have been exposed and continue to be at risk for exposure. It is advisable that individuals affected by this preventable form of cancer speak with a mesothelioma attorney to learn about developing mesothelioma litigation, which may provide them with monetary compensation for the costly bills associated with this disease.

LegalView also offers other information portals ranging from controversial prescription drugs, such as Chantix, Singulair and Digitek, to information on locating a brain injury lawyer to the latest on Nephrogenic Systemic Fibrosis (NSF).

Although lately, the prescription drug scandals have seemingly been on the rise and continue to do so around the country affecting millions of unsuspecting Americans. The Chantix side effects and Singulair risks are a prime example of this. Chantix is a smoking cessation drug that has been reportedly used by millions of Americans until the Food and Drug Administration (FDA) recently released a Public Health Advisory when hundreds of reports on unusual side effects including depression, moodiness, suicidal thoughts and behaviors, began to flood into FDA offices. Patients of Singulair - a treatment of asthma and allergies - began to report similar side effects ranging from erratic behavior to suicidal thoughts.

The most recent prescription drug recall involved Digitek digoxin. The Digitek brand of digoxin is a heart tablet used to treat heart beat irregularity conditions, however after a manufacturing defect resulted in pills with double the dosage, some patients began to report severe cardiac arrest, and some patients taking the drug may have even died because of the Digitek digoxin side effects. To learn more on this, visit http://digitek-digoxin.legalview.com/.

About LegalView:

LegalView.com is a public service brought to you by Legal WebTV Network, LLC, a Limited Liability Corporation created by a group of the nation's most highly respected law firms: Anapol Schwartz; Brent Coon and Associates; Burg Simpson; Cohen, Placitella and Roth; James F. Humphreys and Associates; Lopez McHugh; and Thornton and Naumes. For more information on the accomplishments and track records of LegalView.com's superior sponsoring law firms and to get in touch with LegalView attorneys, visit LegalView at LegalView.com.

Nebivolol Hydrochloride Drug Information

admin — Tue, 16 Dec 2008 18:58:58 +0000

Nebivolol can be used to treat high blood pressure. Nebivolol is indicated as a medicine for Essential Hypertension.

How to Take Nebivolol

Nebivolol is available in tablet form. Nebivolol must only be administered by a qualified healthcare provider. Try to take nebivolol at the same times each day to avoid missing any doses.

What are the Side Effects of Nebivolol -

Like all medicines, Nebivolol can cause some side-effects. Some common side effects reported with this medicine include the following. Call your doctor right away if you notice any of these side effects:

* Headache

* Fatigue

* dizziness

* Paraesthesiasis

* Tiredness,

* coldness of the extremities (fingers, toes and nose),

* disturbed sleep,

* nightmares,

* shortness of breath,

* upset tummy,

* skin rashes,

* dry eyes,

* fluid retention (swelling of the feet and ankles),

* depression,

* problems with eye sight, pins and needles or sexual problems.

Nebivolol intraction with other drugs:

Concomitant administration of chlorthalidone, hydrochlorthiazide, theophylline or digoxin with Nebivolol may reduce its extent of absorption.

Warnings and precautions before taking Nebivolol :

* Nebivolol medicine may reduce your ability to drive or operate machinery safely. Do not drive or operate machinery until you know how Nebivolol affects you and you are sure it won’t affect your performance.

* Do not stop using this Nebivolol medicine suddenly without asking your doctor, or you may develop life-threatening heart problems. You may need to slowly decrease your dose before stopping it completely.

* This medicine (Nebivolol) should not be used during pregnancy.

* Talk with your physician or pharmacist if you are taking other medications.

* Breast Feeding - Problems such as slow heartbeat, low blood pressure, and trouble in breathing have been reported in nursing babies. Mothers who are taking beta-blockers including Nebivolol and who wish to breast-feed should discuss this with their doctor.

What if Overdose of Nebivolol ?

If you think you or anyone else may have taken too many Nebivolol, immediately telephone your doctor or contact your local or regional Poisons Information Centre Seek medical attention immediately. You may need urgent medical attention.

What if Missed Dose of Nebivolol?

If you miss a dose of Nebivolol medicine then contact your doctor if you miss a dose of Nebivolol. Do not double doses.

Storage Conditions for Nebivolol:

Store Nebivolol at room temperature away from moisture and heat. Keep Nebivolol medicine where young children cannot reach them such as a locked cupboard. Never keep out of date or unwanted medicines. Discard them safely out of the reach of children or take them to your local pharmacist who will dispose of them for you.

By: ashu

Lipitor (Atorvastatin) for Hypercholesterolemia Treatment

admin — Fri, 12 Dec 2008 12:05:23 +0000

Generic lipitor, which is used in the treatment of hypercholesterolemia helps in reducing the cholesterol. It also prevents certain types of heart problems and reduces the risk of heart attacks.
Generic lipitor (Atorvastatin) also causes minor and major side effects. Minor ones are mostly temporary. The ones with high intensity need immediate medical attention.
Some side effects produced by generic lipitor are fever, pain, tenderness, blistering, and peeling of skin, cramps and also includes yellow or brown urine. If the intensity of the side effects is more then go to the nearest hospital.
Generic lipitor interacts with certain drugs and certain food items, which in turn increase the intensity of side effects produced by the drug. If you are regularly taking drinks or have a habit of smoking it is better that you inform your physician while he prescribes generic lipitor.
Here are some of the drugs when interact with generic lipitor increases the side effects -
Amiodarone, Barbiturates, Carbamazepine, Digoxin, Diltiazem, Herbal medicines such as Went Yeast, Medicines used for treating fungal infections, cholesterol and HIV infections, Nefazodone, Nicardipine, Oxcarbazepine, Phenytoin and Verapamil.
Before you start using the generic lipitor it is better to ask your doctor
Whether generic lipitor will suit you?
What are the drug interactions and side effects of generic lipitor?
How generic lipitor works and ways to reduce the side effects of generic lipitor?
The recommended dosage of generic lipitor is 10mg once a day. Overdosage can causes serious consequences and requires immediate medical attention. If you have kidney problem or above 65 years of age then you must tell your physician so that he will prescribe the dosage based on your conditions. If you happen to miss the dose, then try to take it as soon as possible. If it is time for next dosage then it is better to leave the missed dosage.
To know more information about generic lipitor visit http://www.internationaldrugmart.com/LIPITOR.html

The Use Of Drugs While Trying To Lose Weight

admin — Thu, 11 Dec 2008 00:55:51 +0000

There are many weight loss drugs and pills available in the open market but not all of them will work for everybody. Many of these drugs and pills contain opiods that can not only be harmful for you initially but also in the long run. The first is the action of combining with other opioid receptors throughout the body which ultimately blocks the impulses of hunger from reaching the brain. This function is similar to that of opiods and nsaids.
It also stops the stomach secretions of digestive juices and nor-epinephrine which in turn inhibits the manner by which the brain picks up hunger signals and food intake impulses are recognized. Stomach Ban is used as a weight reliever for the treatment of moderate as well as chronic obesity. The exact working of stomach ban is not known however, tests reveal that the procedure has two functions. A person who is above the age of 65 would require a slightly altered dose of this drug and such an individual who has had a past dependence upon any opioid or narcotic should not be prescribed this drug. The working of weight loss forum is seen to be effective with weight gain caused by cancer, or hormone and nerve related weight gain and emotional pain which causes an increase in the food intake. Your body needs energy, in fact, in order to lose weight you need energy. As far as the ideal flat tummy goes, you do not need to work your abs more than every two days. You actually don’t know this but they are working all the time until you sleep.
There have been other tests conducted on the procedure to establish if the weight loss supplements would react towards other weigh loss and tummy reduction ways. It was observed that this procedure would have adverse effects if it was used with combination of other serotonin reuptake inhibitors or in combination with MAO inhibitors. Specific reaction to these types of procedures is: Digoxin and Warfarin which are both opioid based pills. It is also advised that the procedure not be used by nursing mothers.