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MUNICH — Patients with heart failure who are treated with digoxin administered according to the standard nomogram risk getting an overdose that might kill them.
“We recommend treating patients who get digoxin with half the dose from the nomogr…

Concepts in clinical pharmacokinetics, 4th ed.
Ed. by Joseph T. DiPiro et al.
Am.Soc./Health-Sys.Pharmacists
2005
230 pages
$99.00
Paperback
RM301
The 15 lessons in this pharmacy textbook define the time course of drug absorption and metabolism in the human body, examine the relationship between drug concentration at the site of action and the resulting effect, …

VANCOUVER, B.C. — The latest Cochrane systematic review of digoxin for treatment of heart failure patients in sinus rhythm paints a picture of a more than 200-year-old drug that’s still clinically useful, although it has no effect on mortality, William B. Hood Jr., M.D., said at a meeting sponsored b…

Digoxin appears to raise the risk of death in stable heart failure, but only in women, according a post hoc analysis of data from a clinical trial.
This finding is based on “robust evidence” and “provides sufficient grounds for a reexamination of the use of digoxin therapy for women with heart failure,” said Saif S. Rathore, a public health specialist at Yale …

To the Editor: Acute mesenteric ischemia occurs in 1 of 1000 hospital admissions, and a nonocclusive mechanism makes up about 20% of these cases. (1) Nonocclusive mesenteric ischemia (NOMI) is a condition where the macrovasculature is patent, but the microvascular blood flow is inadequate to meet intestinal tissue demands leading to gangrene and disastrous consequenc…

Rathore SS, Curtis JP, Wang Y, Bristow MR, Krumholz, HM. Association of serum digoxin concentration and outcomes in patients with heart failure. JAMA 2003; 289:871-878.
* PRACTICE RECOMMENDATIONS
The optimal serum drug concentration for digoxin among men in sinus rhythm with stable heart failure is 0.5 to 0.8 ng/mL. This range is associated with decreased risk of hospitalization and mortality compared with placebo. Higher levels are associated with either no reduc…

Side effects from just three drugs are responsible for a full third of all U.S. emergency room visits by senior citizens who had adverse reactions to medications, a new study found.
In 2004 and 2005, the blood thinner warfarin, the diabetes drug insulin and the heart drug digoxin caused about 58,000 emergency room visits a year in those 65 and older, the researchers found.
The major problem is that it’s hard to determine the correct dose…

PHILADELPHIA — Lannett Co. is working to ensure a supply of the heart failure drug digoxin following a recall of another version of the drug. The FDA said that Digitek tablets may contain twice the amount of the active ingredient, which could put patients at risk, including the possibility of death.

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Digoxin poses risk in womenDe…

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3
Number of drugs (warfarin, insulin and digoxin) that are responsible for a third of all serious …

LegalView updated its mesothelioma blog with information of a woman who was allegedly fired for openly discussing her concerns with asbestos-tainted flooring. The woman, who works at a nursing home beauty salon, claims she…